Haemophilus parasuis gene expression the in lung

ABSTRACT: Purpose: Identify differentially expressed genes in pig lung, compared to growth on chocolate agar plate. Methods: In order to study the gene expression at this location, we sequenced ex vivo and in vivo H. parasuis transcriptome using a metatranscriptomic approach. Gene expression was compared with conventional plate culture. Results: down-regulation of anabolic and catabolic pathways, coupled with up-regulation of membrane-related genes involved in carbon acquisition, iron binding and pathogenesis. Conclusions: This data sheds some light on the scarcely studied in vivo transcriptome of H. parasuis, revealing nutritional virulence as an adaptive strategy for host survival.

ORGANISM(S): Glaesserella parasuis str. Nagasaki

PROVIDER: GSE63851 | GEO | 2014/12/05

SECONDARY ACCESSION(S): PRJNA269254

REPOSITORIES: GEO