Dataset Information


Gene expression profiling of E15.5 FoxD1 Cre;Dicer and control embryonic kidneys

ABSTRACT: The aim of this study is to address the functional role of miRNAs in the FoxD1+ renal stroma progenitors and derivatives during embryonic kidney development. To achieve this, we generated transgenic mice that lack miRNAs in the renal stroma lineage (FoxD1 Cre;Dicer), and performed a microarray analysis on E15.5 whole kidneys to determine the transcriptional changes. Overall design: 3 litters of E15.5 FoxD1 Cre;Dicer and control littermate kidneys were used for the microarray analysis. Each litter consists of kidneys pooled from 2 embryos per genotype for the RNA extraction.

INSTRUMENT(S): Illumina MouseWG-6 v2.0 expression beadchip

SUBMITTER: Dr. Yu Leng Phua  

PROVIDER: GSE64440 | GEO | 2015-11-04



altmetric image


Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.

Phua Yu Leng YL   Chu Jessica Y S JY   Marrone April K AK   Bodnar Andrew J AJ   Sims-Lucas Sunder S   Ho Jacqueline J  

Physiological reports 20151001 10

MicroRNAs are small noncoding RNAs that post-transcriptionally regulate mRNA levels. While previous studies have demonstrated that miRNAs are indispensable in the nephron progenitor and ureteric bud lineage, little is understood about stromal miRNAs during kidney development. The renal stroma (marked by expression of FoxD1) gives rise to the renal interstitium, a subset of peritubular capillaries, and multiple supportive vascular cell types including pericytes and the glomerular mesangium. In th  ...[more]

Similar Datasets

2015-11-04 | E-GEOD-64441 | ArrayExpress
| PRJNA271016 | ENA
2016-02-16 | E-GEOD-76549 | ArrayExpress
2013-11-14 | E-GEOD-52354 | ArrayExpress
2014-08-27 | E-GEOD-60758 | ArrayExpress
| PRJNA271018 | ENA
2015-07-01 | E-GEOD-66079 | ArrayExpress
2015-07-27 | E-GEOD-52354 | ExpressionAtlas
2009-08-07 | E-GEOD-6280 | ArrayExpress
2009-08-01 | GSE6280 | GEO