Transcriptomics,Genomics

Dataset Information

39

Expression profiling of murine inner-ear hair cells


ABSTRACT: Murine auditory and vestibular epithelia were separated into hair-cells (HCs), epithelial non-sensory cells (ENSCs) and non-epithelial cells (NECs) by flow cytometry. Gene expression levels were recorded in independent triplicates from the sorted cells using Illumina whole genome expression microarrays Overall design: Total RNA from 3 cell types (HCs, ENSCs, NECs) isolotaed from 2 inner-ear organs (cochlea and vestibular system)

INSTRUMENT(S): Illumina MouseWG-6 v2.0 expression beadchip

SUBMITTER: Ran Elkon 

PROVIDER: GSE64543 | GEO | 2015-10-12

SECONDARY ACCESSION(S): PRJNA271276

REPOSITORIES: GEO

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Publications


Sensorineural hearing loss is a common and currently irreversible disorder, because mammalian hair cells (HCs) do not regenerate and current stem cell and gene delivery protocols result only in immature HC-like cells. Importantly, although the transcriptional regulators of embryonic HC development have been described, little is known about the postnatal regulators of maturating HCs. Here we apply a cell type-specific functional genomic analysis to the transcriptomes of auditory and vestibular se  ...[more]

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