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ShRNA knockdown of YAP1 in HCC364 cells, various drug conditions


ABSTRACT: Through a genetic screen in BRAF mutant tumor cells, we show that the Hippo pathway effector YAP acts as a parallel survival input to promote resistance to RAF-MEK inhibitor therapy. Our data uncover YAP as a novel mechanism of resistance to RAF-MEK targeted therapy. The findings unveil the synthetic lethality of YAP and RAF-MEK co-suppression as a promising strategy to enhance response and patient survival.

ORGANISM(S): Homo sapiens

PROVIDER: GSE64550 | GEO | 2014/12/30

SECONDARY ACCESSION(S): PRJNA271287

REPOSITORIES: GEO

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