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In vivo effects of localization and/or CXCR4 inhibition on gene expression profiles of OCI-AML3 cells

ABSTRACT: OCI-AML3, a human acute myeloid leukemia cell line, was inoculated into NOD/SCID/IL-2rγnull (NSG) mice. After engraftment and leukemic expansion were documented, mice were divided into 3 groups: control, or treatment for 24 or 72 hours with daily injections of LY2510294, a CXCR4-inhibitory peptide. OCI-AML3 cells were isolated from peripheral blood (PB), bone marrow (BM), or spleen (SP) for gene expression profiling (GEP).

ORGANISM(S): Homo sapiens

PROVIDER: GSE64623 | GEO | 2015/06/03

SECONDARY ACCESSION(S): PRJNA271814

REPOSITORIES: GEO

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