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Transcriptome analyses of the Corynebacterium glutamicum strains adapted to supraoptimal growth temperatures

ABSTRACT: C. glutamicum strains adapted to higher growth temperatures were obtained through an adaptive laboratory evolution experiment. To elucidate molecular basis for thermotolerance acquired by the evolved strains, we examined transcriptional responses of the evolved and parental strains to thermal stress using microarray technology.

ORGANISM(S): Corynebacterium glutamicum Corynebacterium glutamicum R

PROVIDER: GSE64654 | GEO | 2015/01/06

SECONDARY ACCESSION(S): PRJNA271577

REPOSITORIES: GEO

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Transcriptome analyses of the Corynebacterium glutamicum strains adapted to supraoptimal growth temperatures

Project description:C. glutamicum strains adapted to higher growth temperatures were obtained through an adaptive laboratory evolution experiment. To elucidate molecular basis for thermotolerance acquired by the evolved strains, we examined transcriptional responses of the evolved and parental strains to thermal stress using microarray technology. Each strain was grown at the optimal growth temperature (33 M-bM-^DM-^C). When OD610 reached around 7, the growth temperature increased to 41 M-bM-^DM-^C, and transcriptional changes of the evolved and parental strains were examined with microarray technology.

2015-01-06 | E-GEOD-64654 | biostudies-arrayexpress

Corynebacterium glutamicum

Project description:Transcriptome analyses of the Corynebacterium glutamicum strains adapted to supraoptimal growth temperatures

| PRJNA271577 | ENA

Metabolic engineering of Corynebacterium glutamicum for L-arginine production

Project description:Metabolically engineered Corynebacterium glutamicum strains were constructed for the enhanced production of L-arginine, and their gene expression profiles were investigated

2013-11-26 | GSE52737 | GEO

Metabolic engineering of Corynebacterium glutamicum for L-arginine production

Project description:Metabolically engineered Corynebacterium glutamicum strains were constructed for the enhanced production of L-arginine, and their gene expression profiles were investigated Gene expression profiles of two C. glutamicum strains AR2 and AR6 were examined for the 3043 genes twice.

2013-11-26 | E-GEOD-52737 | biostudies-arrayexpress

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Project description:Corynebacterium glutamicum (thermal-adapted strain) genome sequencing project

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A compendium of expression profiles for Corynebacterium glutamicum ATCC13032 [no raw data]

Project description:Transcriptional profiling of C. glutamicum wild-type and mutant strains grown under different conditions.

2022-07-22 | GSE171301 | GEO

A compendium of expression profiles for Corynebacterium glutamicum ATCC13032 [with raw data]

Project description:Transcriptional profiling of C. glutamicum wild-type and mutant strains grown under different conditions.

2022-07-22 | GSE169361 | GEO

Gene expression patterns of pediocin-producing Corynebacterium glutamicum strains

Project description:Strains: non-producing refernece strain pXMJ19 (CR099 pXMJ19; Goldbeck et al., 2021) and Pediocin-producer pxMJ19 ped (CR099 pXMJ19 Ptac pedACDCg, Goldbeck et al., 2021) Pediocin-producing and non-producing strains of Corynebacterium glutamicum were compared in a whole genome microarray analysis setup in order to identify potential strain optimization targets

2023-03-08 | GSE220713 | GEO

Ciprofloxacin triggers L-glutamate production by Corynebacterium glutamicum

Project description:Ciprofloxacin, an inhibitor of bacterial gyrase and topoisomerase IV, was shown to inhibit growth of C. glutamicum with concomitant excretion of L-glutamate. C. glutamicum strains overproducing L-lysine, L-arginine, L-ornithine, and putrescine, respectively, produced L-glutamate instead of the desired amino acid when exposed to ciprofloxacin. Even in the absence of the putative L-glutamate exporter gene yggB, ciprofloxacin effectively triggered L-glutamate production. When C. glutamicum wild type was cultivated under nitrogen-limiting conditions, 2-oxoglutarate rather than L-glutamate was produced as consequence of exposure to ciprofloxacin. Transcriptome analysis revealed that ciprofloxacin increased RNA levels of genes involved in DNA synthesis, repair and modification. Enzyme assays showed that 2-oxoglutarate dehydrogenase activity was decreased due to ciprofloxacin addition. Here, it was shown for the first time that production of L-glutamate by C. glutamicum may be triggered by an inhibitor of DNA synthesis and L-glutamate titers of up to 37 ± 1 mM and a substrate specific L-glutamate yield of 0.13 g/g were reached.

2016-01-26 | GSE77189 | GEO

Comparison of Corynebacterium glutamicum Δcg2699 with WT

Project description:To identify genes which are differentially expressed in Corynebacterium glutamicum in the cg2699 deletion strain, we performed DNA microarray analyses of C. glutamicum Δcg2699 compared to the WT.

2018-08-28 | GSE117566 | GEO

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