LRH1 silencing inhibits human colon cancer growth.

ABSTRACT: This study was undertaken to better determine the function of LRH-1 (NR5A2) in the colorectal cancers (CRC) through inducible shRNA-mediated knockdown within well-established CRC cell line Caco-2 Our work is the first to demonstrate that silencing of LRH-1 in established human CRC cell lines impairs proliferation though G0/G1 phase prolongation, and alteration in diverse cellular pathways consistent with the critical role of LRH-1 in CRC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE64695 | GEO | 2015/02/24

SECONDARY ACCESSION(S): PRJNA271662

REPOSITORIES: GEO