Dataset Information


Mode of action analysis: Distinct Staphylococcus aureus transcriptome changes upon antivirulence hydroxy amide treatment

ABSTRACT: To elucidate the antivirulent hydroxy amide (R*,R*)-3 mode of action, next generation sequencing was applied to analyze the transcriptome of NCTC 8325 cells treated with either compound or DMSO as control. Overall design: Two biological replicates for compound treated and also two biological replicates for DMSO treated Staphylococcus aureus cultures were analysed.

INSTRUMENT(S): Illumina HiSeq 2500 (Staphylococcus aureus)

SUBMITTER: Jan Vomacka 

PROVIDER: GSE64747 | GEO | 2016-01-14



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An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression.

Vomacka Jan J   Korotkov Vadim S VS   Bauer Bianca B   Weinandy Franziska F   Kunzmann Martin H MH   Krysiak Joanna J   Baron Oliver O   Böttcher Thomas T   Lorenz-Baath Katrin K   Sieber Stephan A SA  

Chemistry (Weinheim an der Bergstrasse, Germany) 20160108 5

Methicillin-resistant Staphylococcus aureus (MRSA) causes severe infections with only few effective antibiotic therapies currently available. To approach this challenge, chemical entities with a novel and resistance-free mode of action are desperately needed. Here, we introduce a new hydroxyamide compound that effectively reduces the expression of devastating toxins in various S. aureus and MRSA strains. The molecular mechanism was investigated by transcriptome analysis as well as by affinity-ba  ...[more]

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