Whole-genome DNA methylation map of japanese macaque sperm

ABSTRACT: It has been thought that epigenetic changes underlie the evolutionary divergence of phenotype between closely related species. However, the manner in which epigenetic changes are generated remains unknown. Although whole-genome DNA methylation profiles in some somatic tissues and sperm have been reported for humans and chimpanzees, a systematic analysis of these data has been lacking. In this manuscript, therefore, we analyzed these methylomes in detail, identified genomic regions with different DNA methylation levels, and examined the cell-type specificity and its association with changes in genomic sequence. Moreover, we generated a methylation map of Japanese macaque sperm and used it as an out-group to infer the evolutional history of methylation in these regions.

ORGANISM(S): Macaca fuscata

PROVIDER: GSE64829 | GEO | 2017/01/22

SECONDARY ACCESSION(S): PRJNA272129

REPOSITORIES: GEO