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Investigation of the role of PRL-3 in leukemogenesis

ABSTRACT: In order to investigate the role of PRL-3 in the leukemogenesis, we transfected a control vector (pEGFP) and (human) PRL-3 gene into an acute myeloid leukemia (AML) cell line TF-1, respectively. After drug selection and FACS sorting, we established TF1-pEGFP and TF1-hPRL-3 isogenic cell lines. In vitro and in vivo experiments were conducted to characterized this pair of isogenic cell lines. Results provided insight into the molecular basis of PRL-3 in contributing the development of AML.

ORGANISM(S): Homo sapiens

PROVIDER: GSE64872 | GEO | 2017/01/11

SECONDARY ACCESSION(S): PRJNA272424

REPOSITORIES: GEO

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