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Single Cell triple omics sequencing reveals genetic and epigenetic heterogeneity in hepatocellular carcinoma

ABSTRACT: Single cell genome, DNA methylome, and transcriptome sequencing has been achieved separately. However, to analyze the regulation of RNA expression by genetic and epigenetic factors within an individual cell, it is necessary to analyze these omics simultaneously from the same single cell. Here we developed a single cell triple omics sequencing technique- scTrio-seq, to analyze the genome, DNA methylome, and transcriptome concurrently of a mammalian cell.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE65364 | GEO | 2016/03/01

SECONDARY ACCESSION(S): PRJNA273802

REPOSITORIES: GEO

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Single Cell triple omics sequencing reveals genetic and epigenetic heterogeneity in hepatocellular carcinoma

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