Transcriptional correlates of FOXP3 expression in suppressive and non-suppressive primary human Treg cell clones.

ABSTRACT: Analysis of the transcriptional correlates of FOXP3 expression in suppressive and non-suppressive primary human Treg cell clones. Individual CD4+CD25High or Cd4+CD25- T cells were isolated from human PBMCs and expanded in vitro. After 3 weeks of expansion, individual clones were analysed for FOXP3 expression and in vitro suppressive activity against freshly sorted allogeneic effector T cells. This study analyses the total RNA isolated from FOXP3+ clones with suppressive potency to their non-suppressive counterparts. The resutls of this study should provide insights into the molecular pathways linking FOXP3 expression to distinct aspects of Treg phenotype and function.

ORGANISM(S): Homo sapiens

PROVIDER: GSE65650 | GEO | 2015/05/06

SECONDARY ACCESSION(S): PRJNA274579

REPOSITORIES: GEO