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Omics score: 1045

Transcriptome profiling in knock-in mouse models of Huntington's disease [Striatum_mRNA]

ABSTRACT: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding huntingtin (Htt). Knock-in mouse models of HD with human exon 1 containing expanded CAG repeats inserted in the murine huntingtin gene (Hdh) provide a genetic reconstruction of the human causative mutation within the mouse model. The goal of this study is RNA expression profiling by RNA sequencing (RNA-seq) in 2, 6, and 10 month old knock-in mice with CAG lengths of 20, 80, 92, 111, 140, 175 along with littermate control wild-type animals Overall design: mRNA expression profiles were obtained via RNA-seq analysis performed on tissue samples from the striatum of 2, 6, and 10 month old knock-in mice with CAG lengths of 20, 80, 92, 111, 140, 175 along with littermate control wild-type animals.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

ORGANISM(S): Mus Musculus

SUBMITTER: Jeff Aaronson

PROVIDER: GSE65774 | GEO |

SECONDARY ACCESSION(S): PRJNA274985

REPOSITORIES: GEO

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			Action	DRS
	GSE65774_Striatum_mRNA_FPKM_processedData.txt.gz	Txt
	GSE65774_Striatum_mRNA_counts_processedData.txt.gz	Txt

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