Ontology highlight
ABSTRACT:
INSTRUMENT(S): [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
SUBMITTER: Wilfried Gouraud
PROVIDER: GSE65777 | GEO | 2016-11-23
SECONDARY ACCESSION(S): PRJNA275004
REPOSITORIES: GEO
Magrangeas Florence F Kuiper Rowan R Avet-Loiseau Hervé H Gouraud Wilfried W Guérin-Charbonnel Catherine C Ferrer Ludovic L Aussem Alexandre A Elghazel Haytham H Suhard Jérôme J Sakissian Henri Der H Attal Michel M C Munshi Nikhil N Sonneveld Pieter P Dumontet Charles C Moreau Philippe P van Duin Mark M Campion Loïc L Minvielle Stéphane S
Clinical cancer research : an official journal of the American Association for Cancer Research 20160408 17
Painful peripheral neuropathy is a frequent toxicity associated with bortezomib therapy. This study aimed to identify loci that affect susceptibility to this toxicity.A genome-wide association study (GWAS) of 370,605 SNPs was performed to identify risk variants for developing severe bortezomib-induced peripheral neuropathy (BiPN) in 469 patients with multiple myeloma who received bortezomib-dexamethasone therapy prior to autologous stem cell in randomized clinical trials of the Intergroupe Franc ...[more]