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Comparison of gene expression data from human and mouse breast cancers: Identification of conserved breast tumor genes

ABSTRACT: The aim of our work was the comparison of human and mouse gene expression data and to identify a conserved breast tumor gene set. The results encourage the usefulness of transgenic mice as a model for human breast cancer formation and therapy. Keywords: Comparison of gene expression data

ORGANISM(S): Homo sapiens

PROVIDER: GSE6596 | GEO | 2007/01/12

SECONDARY ACCESSION(S): PRJNA104185

REPOSITORIES: GEO

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Comparison of gene expression data from human and mouse breast cancers: Identification of conserved breast tumor genes

Project description:The aim of our work was the comparison of human and mouse gene expression data and to identify a conserved breast tumor gene set. The results encourage the usefulness of transgenic mice as a model for human breast cancer formation and therapy. Keywords: Comparison of gene expression data The aim of our work was to establish a database for breast cancer gene expression data in order to compare human and mouse breast cancer. We identified human and mouse homologues genes and compared the expression profile of 24 human breast tumors with six WAP-SVT/t breast tumors (WAP-SVT/t animals, line 8). Our studies confirmed the heterogeneity in gene expression of human as well as mouse breast cancer cells. However, 63 genes were found to be differentially expressed (upregulated: 40; downregulated: 23 genes) in at least 75% of the breast tumors of both species.

2007-01-12 | E-GEOD-6596 | biostudies-arrayexpress

Expression data from mammary glands of transgenic mice

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Project description:The aim of our work was the comparison of human and mouse gene expression data and to identify a conserved breast tumor gene set. The results encourage the usefulness of transgenic mice as a model for human breast cancer formation and therapy. Experiment Overall Design: The aim of our work was to establish a database for breast cancer gene expression data in order to compare human and mouse breast cancer. We identified human and mouse homologues genes and compared the expression profile of 24 human breast tumors with six WAP-SVT/t breast tumors (WAP-SVT/t animals, line 8). Our studies confirmed the heterogeneity in gene expression of human as well as mouse breast cancer cells. However, 63 genes were found to be differentially expressed (upregulated: 40; downregulated: 23 genes) in at least 75% of the breast tumors of both species.

2008-06-14 | E-GEOD-6581 | biostudies-arrayexpress

Transcription profiling of human and mouse breast cancers

Project description:This SuperSeries is composed of the following subset Series:; GSE6581: Expression data from mammary glands of transgenic mice; GSE6596: Comparison of gene expression data from human and mouse breast cancers: Identification of conserved breast tumor genes Experiment Overall Design: Refer to individual Series

2008-06-15 | E-GEOD-6772 | biostudies-arrayexpress

Gene expression profiling of 30 human breast cancers

Project description:We used microarrays to profile 30 human primary breast tumors and determine global gene expression patterns and molecular subtypes Keywords: Basal gene expression in human tumor samples

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Comparison between Estrogen receptor positive and Estrogen receptor negative breast cancer samples

Project description:Comparison between Estrogen receptor positive and Estrogen receptor negative breast cancer samples Keywords: breast cancer type comparison

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Project description:Gene expression profiling of human and dog breast cancers

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Comparison between Estrogen receptor positive and Estrogen receptor negative breast cancer samples

Project description:Comparison between Estrogen receptor positive and Estrogen receptor negative breast cancer samples Keywords: breast cancer type comparison 152 unique breast cancer tissue sample are included in the analysis. The total mRNA has been labeled with Cy5 and then hybridized on a two color arrays against the stratagen Human common reference that was previously labelled with Cy3.

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Transcription profiling of human breast cancers (30)

Project description:We used microarrays to profile 30 human primary breast tumors and determine global gene expression patterns and molecular subtypes Experiment Overall Design: RNA from SNAP frozen human tumor biopsies was analyzed on Affymetrix mircroarrays

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CPTAC, TCGA Breast Cancer Proteome Study Comparison and Reference Samples (CompRef)

Project description:Comparison and Reference (CompRef) Samples, initially characterized in the <a href="https://cptac-data-portal.georgetown.edu/cptac/s/S010" target="_blank">System Suitability Study</a>, were analyzed along with the TCGA Breast Cancer tumor samples. These 5 iTRAQ experiments include proteome and phosphoproteome interrogation of both the P5 (basal) and P6 (luminal) human-in-mouse xenograft breast carcinoma pooled samples. The CompRef experiments were intercalated between the TCGA Breast Cancer experiments to monitor the consistency of laboratory protocols and mass spectrometry instrument performance.<ul><li>Dataset imported into MassIVE from <a href="https://cptac-data-portal.georgetown.edu/cptac/s/S018">https://cptac-data-portal.georgetown.edu/cptac/s/S018</a> on 08/25/19</li></ul>

2019-08-25 | MSV000084233 | MassIVE

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