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Histone H3 globular domain acetylation identifies new class of enhancers

ABSTRACT: We report the acetylation of lysine residues in the globular domain of H3 (H3K64ac and H3K122ac) marks active gene promoters and also a subset of active enhancers in mouse embryonic stem cells (mESCs), human erythroleukemic cell line (K562). Moreover, we find a novel class of active functional enhancers in ESCs that are marked by H3K122ac but which lack H3K27ac. This work suggests that a more complex analysis of histone acetylation is required to identify enhancers than was previously considered.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE66023 | GEO | 2016/03/12

SECONDARY ACCESSION(S): PRJNA275703

REPOSITORIES: GEO

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Histone H3 globular domain acetylation identifies novel enhancers

Project description:We report the acetylation of lysine residues in the globular domain of H3 (H3K64ac and H3K122ac) marks active gene promoters and also a subset of active enhancers in mouse embryonic stem cells (mESCs), human erythroleukemic cell line (K562). Moreover, we find a novel class of active functional enhancers in ESCs that are marked by H3K122ac but which lack H3K27ac. This work suggests that a more complex analysis of histone acetylation is required to identify enhancers than was previously considered. Examination of histone modifications in mouse ESCs (2 biological replicates) and K562 cells

2016-03-12 | E-GEOD-66023 | biostudies-arrayexpress

Histone H3 globular domain acetylation identifies new class of enhancers

Project description:Histone H3 globular domain acetylation identifies new class of enhancers

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Transcriptional regulation by H3K122 acetylation in the lateral surface of the histone octamer

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Transcription profiling of soybean SRB embryo regions at the globular stage

Project description:We microdissected each embryo region from 6-micron paraffin sections using the Leica AS LMD system to identify all genes active in different embryo region of an SRB seed containing globular-stage embryos. Experiment Overall Design: Globular-stage embryo regions were isolated using the Leica AS LMD system. Total RNA was amplified and hybridized with Affymetrix Soybean Genome GeneChip Arrays.

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Expression data from SRB embryo regions at the globular stage

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Expression data from soybean seed compartments with embryos at the globular stage

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H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction (I) [ChIP-Seq]

Project description:We report that acetylation of H4K16 is a new marker of active enhancers and that some enhancers are marked by H3K4me1, MOF and H4K16ac but not by acetylated H3K27 or p300, suggesting that they are novel p300-independent regulatory elements. ChIP-seq for H4K16 acetylation in undifferentiated ES cells, and cells after 3 days of retinoic acid differentiation, along with MNase digested input for both samples

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