Genomics

Dataset Information

42

Liver Expression Profiling In HMDP (Atherosclerosis F1 study)


ABSTRACT: Identify genes in the liver whose expression is under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HMDP comprises classical inbred and recombinant inbred wild type mice. 104 of these strains were bred onto a C57BL/6J background carrying transgenes for both ApoE-Leiden and cholesteryl ester transfer protein (CETP). The RMA values of genes were used for genome wide association as described in Davis et al PLOS Genetics 2015. These data are used to identify candidate genes at loci associated with atherosclerotic lesion size. Overall design: GWAS for expression in livers of F1 offspring of inbred strains crossed with C57BL/6J carrying ApoE-Leiden and CETP transgenes fed chow diet for 8 weeks followed by Western diet for 16 weeks

INSTRUMENT(S): [HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate

SUBMITTER: Calvin Pan 

PROVIDER: GSE66568 | GEO | 2016-01-25

SECONDARY ACCESSION(S): PRJNA277341

REPOSITORIES: GEO

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Publications


Common forms of atherosclerosis involve multiple genetic and environmental factors. While human genome-wide association studies have identified numerous loci contributing to coronary artery disease and its risk factors, these studies are unable to control environmental factors or examine detailed molecular traits in relevant tissues. We now report a study of natural variations contributing to atherosclerosis and related traits in over 100 inbred strains of mice from the Hybrid Mouse Diversity Pa  ...[more]

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