Genomics

Dataset Information

0

Copy number analysis of DCIS with and without recurrence


ABSTRACT: We analysed a cohort of pure DCIS cases treated only with wide local excision for genome-wide copy number and loss of heterozygosity using Affymetrix OncoScan® MIP arrays. Cases included those without recurrence within 6 years (n=25) and with recurrence between 1-5 years after diagnosis (n=15). Additional cases were excluded for low grade (n=6) or non-clonal recurrence (n=2). Recurrence tumour was available for 8 cases. Pure DCIS were broadly similar in copy number changes compared to invasive breast cancer, with the consistent exception of a greater frequency of ERBB2 amplification in DCIS. There were no significant differences in age or ER status between the cases with a recurrence versus those without. Overall, the DCIS cases with recurrence had more copy number events than the DCIS without recurrence. The increased copy number appeared non-random with several genomic regions showing an increase in frequency in recurrent cases including 20q gain, ERBB2 amplification and 15q loss. Copy number changes may provide prognostic information for DCIS recurrence but validation in additional cohorts is required.

ORGANISM(S): Homo sapiens

PROVIDER: GSE66746 | GEO | 2015/12/01

SECONDARY ACCESSION(S): PRJNA277850

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

| PRJNA277850 | ENA
2016-12-22 | GSE92697 | GEO
2015-07-25 | E-GEOD-69240 | biostudies-arrayexpress
2015-07-25 | GSE69240 | GEO
2015-07-25 | GSE69993 | GEO
2015-07-25 | E-GEOD-69993 | biostudies-arrayexpress
2009-02-01 | GSE10197 | GEO
2020-01-29 | GSE131087 | GEO
2008-04-04 | E-GEOD-11042 | biostudies-arrayexpress
2009-01-05 | GSE13021 | GEO