Genomics

Dataset Information

47

MicroRNAs expression in kidneys from normal, cisplatin induced AKI rats and those with the restoration of MSCs


ABSTRACT: The availability of mesenchymal stem cells in kidney injury repair has been demonstrated. However, the underlying molecular mechanism remains not well understood. Herein, we profiled the altered microRNAs in renal tissiues from cisplatin-induced acute kidney injury (AKI) rats administrated with or without rat bone marrow mesenchymal stem cells, normal kidneys as control. Sprague Dawley rats were administrated with PBS by caudal vein after 24h peritoneal injection of 6mg/mg cisplatin, short for g2. 1×106 MSCs were injected to rats after 24h peritoneal injection of cisplatin, short for g3. Kidneys from healthey rats were used as control, short for g1. Renal tissues were collected at day 5 after treatment. There were 44 micorRNAs changed with significance between g2 and g3, among which 36 microRNAs upregulated and 8 microRNAs downregulated. Overall design: Cisplatin induced microRNAs expression in kidneys were profiled after administrated with PBS or MSCs for 4 days. In g2 and g3,three independent experiments were performed, while two in g1.

INSTRUMENT(S): Agilent-031189 Unrestricted_Rat_miRNA_v16.0_Microarray (miRNA ID version)

SUBMITTER: Yuan Zhu 

PROVIDER: GSE66761 | GEO | 2015-03-11

SECONDARY ACCESSION(S): PRJNA277873

REPOSITORIES: GEO

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Publications

MicroRNA-146b, a Sensitive Indicator of Mesenchymal Stem Cell Repair of Acute Renal Injury.

Zhu Yuan Y   Yu Jing J   Yin Lei L   Zhou Ying Y   Sun Zixuan Z   Jia Haoyuan H   Tao Yang Y   Liu Wanzhu W   Zhang Bin B   Zhang Jiao J   Wang Mei M   Zhang Xu X   Yan Yongmin Y   Xue Jianguo J   Gu Hongbin H   Mao Fei F   Xu Wenrong W   Qian Hui H  

Stem cells translational medicine 20160708 10


: The role of mesenchymal stem cells (MSCs) in kidney injury repair has been studied widely. However, the underlying molecular mechanism remains unclear. We profiled the altered microRNAs in renal tissues from cisplatin-induced acute kidney injury (AKI) rats treated with or without rat bone marrow MSCs (rMSCs). We observed that microRNA-146b (miR-146b) expression was considerably upregulated in renal tissues from AKI rats compared with that in healthy rats, and the expression decreased following  ...[more]

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