RNA-seq analysis of gene expression patterns responding to TSA treatment during hESC neural differentiation

ABSTRACT: We report the differential roles of an HDAC inhibitor-TSA during hESC nerual commitment. In the initiation of hESC differentiation, TSA could inhibit the downregulation of pluripotency genes to maintain pluripotency, whereas in the neural commitment stage, TSA could promote neural gene expression to assist hESC nerual determination.

ORGANISM(S): Homo sapiens

PROVIDER: GSE66777 | GEO | 2015/03/11

SECONDARY ACCESSION(S): PRJNA277945

REPOSITORIES: GEO