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Expression data from human colonic cancer cell line SW480 and its acquired 17-AAG resistance cell line SW480-R

ABSTRACT: Heat shock protein 90 (HSP90) is a molecular chaperone required for the stability and function of many proteins. The chaperoning of oncoproteins by HSP90 enhances survival, growth and invasive potential of cancer cells. HSP90 inhibitors are promising new anticancer agents, in which the benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin (17-AAG) is currently in clinical evaluation. However, the implications of acquired resistance to this class of drug remain largely unexplored. In the present study, we have generated isogenic human colonic cancer cell line SW480 that is resistant to 17-AAG by continued culturing in the compound. We used microarrays to detail the global programme of gene expression underlying the acquired resistance to 17-AAG in SW480 and SW480-R cell lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE66867 | GEO | 2015/03/14

SECONDARY ACCESSION(S): PRJNA278131

REPOSITORIES: GEO

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