Genomics

Dataset Information

22

Cyclodextrin promotes atherosclerosis regression via LXR activation


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina MouseWG-6 v2.0 expression beadchip

SUBMITTER: Joachim Schultze  

PROVIDER: GSE67014 | GEO | 2016-05-06

SECONDARY ACCESSION(S): PRJNA278711 GSE67011 GSE67013

REPOSITORIES: GEO

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Publications


Atherosclerosis is an inflammatory disease linked to elevated blood cholesterol concentrations. Despite ongoing advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains the leading cause of death worldwide. Continuous retention of apolipoprotein B-containing lipoproteins in the subendothelial space causes a local overabundance of free cholesterol. Because cholesterol accumulation and deposition of cholesterol crystals (CCs) trigger a complex inflammatory respon  ...[more]

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