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Profiling gene expression in M. tuberculosis under different in vitro conditions.

ABSTRACT: This RNA-Seq study of gene expression in M. tuberculosis was done as part of the FLUTE project (NIH grant U19-AI107774, Eric Rubin, program director).

ORGANISM(S): Mycobacterium tuberculosis HN878 Mycobacterium tuberculosis H37Rv

PROVIDER: GSE67035 | GEO | 2016/03/30

SECONDARY ACCESSION(S): PRJNA278760

REPOSITORIES: GEO

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Profiling gene expression in M. tuberculosis under different in vitro conditions.

Project description:This RNA-Seq study of gene expression in M. tuberculosis was done as part of the FLUTE project (NIH grant U19-AI107774, Eric Rubin, program director). There are 3 replicates each for Mtb H37Rv grown under the following conditions: 0.1% butyrate, 0.4% glucose, butyrate+glucose, low iron, acidic conditions, and several RIF-resistant mutants of Beijing strain HN878 with different mutations in RpoB.

2016-03-30 | E-GEOD-67035 | biostudies-arrayexpress

Gene expression profiling of knock-out of Rv2869c/Rip1 in M. tuberculosis Erdman and Rv3193c in M. tuberculosis H37Rv

Project description:This RNA-Seq study of gene expression in M. tuberculosis was done as part of the FLUTE project (NIH grant U19-AI107774, Eric Rubin, program director).

2023-01-01 | GSE67670 | GEO

Molecular basis of flowering under natural long-day conditions in Arabidopsis

Project description:Plants sense light and temperature changes to regulate flowering time. The expression of the florigen gene, FLOWERING LOCUS T (FT), peaks in the morning during spring, a different pattern than we observe in the lab. Providing our lab growth conditions with a red/far-red light ratio similar to open field conditions and average natural temperature oscillation is sufficient to mimic the FT expression and flowering time in natural long days. Here, we use RNA-seq to identify and understand the molecular differences between natural growth conditions, conventional lab growth conditions, and supplemented lab growth conditions that mimic natural conditions. Non-NIH grant(s): Grant ID: NSF 1656076 Grant title: Exploring Seasonal Flowering Mechanisms Affiliation: University of Washington Name: Takato Imaizumi

2018-04-01 | GSE110605 | GEO

Gene expression analysis of Mycobacterium tuberculosis under arginine conditions

2015-04-01 | GSE67445 | GEO

Gene expression analysis of Mycobacterium tuberculosis under arginine conditions

Project description:In other bacteria, arginine induces the expression of genes involved in arginine catabolism. This study obtained the identification of genes involved in the arginine metabolism of Mycobacterium tuberculosis. Mycobacterium tuberculosis was cultured with arginine or ammonium chloride as sole nitrogen source. In the log phase of growth, RNA was isolated and whole genome expression was determined. The study contains three biological replicates.

2015-04-01 | E-GEOD-67445 | biostudies-arrayexpress

Carbon sources tune antibiotic susceptibility in Pseudomonas aeruginosa via TCA cycle control

Project description:This study examines the mechanisms underlying fumarate- and glyoxylate-mediated changes in tobraymcyin sensitivity in PAO1 cells Grant ID: NIH Grant K99 GM 118907 Grant title: Effects of Host Metabolic Variation on Antibiotic Susceptibility Funding Source: NIH NIGMS Name: Jason Yang

2016-12-20 | GSE90620 | GEO

Rhesus Macaque Model of Mismatch Repair-Deficient Colorectal Cancer

Project description:This SuperSeries is composed of the SubSeries listed below. NIH grant(s): Grant ID: 5 P30 CA016672-44 Grant title: Cancer Center Support Grant Affiliation: The University of Texas MD Anderson Cancer Center Grantor: NCI

2022-03-31 | GSE178383 | GEO

Effect of small M. tuberculosis RNA MTS1338 on the transcriptome under various stress conditions

Project description:The study was carried out to study the effect of small RNA MTS1338 on the M. tuberculosis transcriptome under various stress conditions (low pH, oxidative and nitrosative stress) .

2023-05-17 | GSE218354 | GEO

Gene expression profling of Mycobacterium tuberculosis H37Rv and H37RvΔdosSΔdosT in 0.2% glucose/acetate under aerobic/hypoxic conditions

Project description:The present study reports the gene expression data of Mycobacterium tuberculosis H37Rv and H37RvΔdosSΔdosT (DKO) grown on 0.2 % acetate/glucose under aerobic/hypoxic conditions. Acetate was reported to be present in granulomas of Mycobacterium tuberculosis infected guinea pigs which are also hypoxic. By exposing Mycobacterium tuberculosis H37Rv and H37RvΔdosSΔdosT to different combinations of granulomatous stresses (acetate/glucose and aerobic/hypoxic conditions) alongwith other experimental data, we were able to delineate a new signaling pathway that activates DevR (DosR) regulon through Acetyl phosphate. The presence of two pathways highlights the importance of targeting DevR and not DevS/DosT for intercepting DevRST signalling cascade.

2019-01-01 | GSE117428 | GEO

Transcriptional profile of Mycobacterium tuberculosis in an in vitro model of intraocular tuberculosis

Project description:We studied M. tuberculosis transcriptome by whole genome microarray for the identification of key pathogenic determinants that are involved in the pathogenesis of intraocular tuberculosis.

2018-06-05 | GSE115292 | GEO

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