Transcriptomics,Genomics

Dataset Information

47

Expression data from epidermal samples


ABSTRACT: Gene expression profiling of epidermal samples obtained from sun-exposed and sun-protected body sites from younger (<35 years old) and older (>60 years old) individuals. The Affymetrix U133A plus 2.0 array was used to obtain gene expression data. Samples included 4 younger sun exposed epidermal samples, 4 older sun exposed epidermal samples, 3 younger sun protected epidermal samples, 5 older sun protected epidermal samples. Overall design: To determine how gene expression relates to identified methylation changes with aging and sun-exposure, RNA was extracted from dispase separated epidermal samples and analyzed using Affymetrix U133A plus 2.0 arrays.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Andrew Feinberg 

PROVIDER: GSE67098 | GEO | 2015-03-23

SECONDARY ACCESSION(S): PRJNA278945

REPOSITORIES: GEO

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Publications

Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin.

Vandiver Amy R AR   Irizarry Rafael A RA   Hansen Kasper D KD   Garza Luis A LA   Runarsson Arni A   Li Xin X   Chien Anna L AL   Wang Timothy S TS   Leung Sherry G SG   Kang Sewon S   Feinberg Andrew P AP  

Genome biology 20150416


Aging and sun exposure are the leading causes of skin cancer. It has been shown that epigenetic changes, such as DNA methylation, are well established mechanisms for cancer, and also have emerging roles in aging and common disease. Here, we directly ask whether DNA methylation is altered following skin aging and/or chronic sun exposure in humans.We compare epidermis and dermis of both sun-protected and sun-exposed skin derived from younger subjects (under 35 years old) and older subjects (over 6  ...[more]

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