Genomics

Dataset Information

34

Effect of S534A substitution in the p65 subunit of Nfkb on response to 1mg LPS


ABSTRACT: WT mice and Nfkb/p65 S534A were exposed to 1mg/kg LPS and their gene expression measured. Affymetrix Mouse 1.0ST chips were used to measure gene expression. Overall design: Gene expression of the following mouse livers were characterized WT untreated (n=4). WT treated with 1mg/kg LPS (n=4). S534A treated with 1mg/kg LPS (n=4). S534A untreated 1mg/kg LPS (n=4).

INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Robert F Schwabe  

PROVIDER: GSE67178 | GEO | 2017-04-05

SECONDARY ACCESSION(S): PRJNA279183

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE67178_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 2 of 2
altmetric image

Publications

Negative regulation of NF-κB p65 activity by serine 536 phosphorylation.

Pradère Jean-Philippe JP   Hernandez Céline C   Koppe Christiane C   Friedman Richard A RA   Luedde Tom T   Schwabe Robert F RF  

Science signaling 20160823 442


Nuclear factor κB (NF-κB) is a master regulator of inflammation and cell death. Whereas most of the activity of NF-κB is regulated through the inhibitor of κB (IκB) kinase (IKK)-dependent degradation of IκB, IKK also phosphorylates subunits of NF-κB. We investigated the contribution of the phosphorylation of the NF-κB subunit p65 at the IKK phosphorylation site serine 536 (Ser(536)) in humans, which is thought to be required for the activation and nuclear translocation of NF-κB. Through experime  ...[more]

Similar Datasets

2017-04-05 | GSE67072 | GEO
2015-01-01 | S-EPMC4464284 | BioStudies
2020-01-01 | S-EPMC7251840 | BioStudies
2020-01-01 | S-EPMC7472845 | BioStudies
1000-01-01 | S-EPMC3832860 | BioStudies
2016-01-01 | S-EPMC5327697 | BioStudies
2020-01-01 | S-EPMC7253404 | BioStudies
2017-01-01 | S-EPMC5472224 | BioStudies
2011-01-01 | S-EPMC3217009 | BioStudies
2019-01-01 | S-EPMC6537024 | BioStudies