Ontology highlight
ABSTRACT:
INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
SUBMITTER: Robert F Schwabe
PROVIDER: GSE67178 | GEO | 2017-04-05
SECONDARY ACCESSION(S): PRJNA279183
REPOSITORIES: GEO
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Pradère Jean-Philippe JP Hernandez Céline C Koppe Christiane C Friedman Richard A RA Luedde Tom T Schwabe Robert F RF
Science signaling 20160823 442
Nuclear factor κB (NF-κB) is a master regulator of inflammation and cell death. Whereas most of the activity of NF-κB is regulated through the inhibitor of κB (IκB) kinase (IKK)-dependent degradation of IκB, IKK also phosphorylates subunits of NF-κB. We investigated the contribution of the phosphorylation of the NF-κB subunit p65 at the IKK phosphorylation site serine 536 (Ser(536)) in humans, which is thought to be required for the activation and nuclear translocation of NF-κB. Through experime ...[more]