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Effect of S534A substitution in the p65 subunit of Nfkb on response to 1mg LPS

ABSTRACT: WT mice and Nfkb/p65 S534A were exposed to 1mg/kg LPS and their gene expression measured. Affymetrix Mouse 1.0ST chips were used to measure gene expression. Overall design: Gene expression of the following mouse livers were characterized WT untreated (n=4). WT treated with 1mg/kg LPS (n=4). S534A treated with 1mg/kg LPS (n=4). S534A untreated 1mg/kg LPS (n=4).

INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Robert F Schwabe  

PROVIDER: GSE67178 | GEO | 2017-04-05



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Negative regulation of NF-κB p65 activity by serine 536 phosphorylation.

Pradère Jean-Philippe JP   Hernandez Céline C   Koppe Christiane C   Friedman Richard A RA   Luedde Tom T   Schwabe Robert F RF  

Science signaling 20160823 442

Nuclear factor κB (NF-κB) is a master regulator of inflammation and cell death. Whereas most of the activity of NF-κB is regulated through the inhibitor of κB (IκB) kinase (IKK)-dependent degradation of IκB, IKK also phosphorylates subunits of NF-κB. We investigated the contribution of the phosphorylation of the NF-κB subunit p65 at the IKK phosphorylation site serine 536 (Ser(536)) in humans, which is thought to be required for the activation and nuclear translocation of NF-κB. Through experime  ...[more]

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