Genomics

Dataset Information

46

Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus


ABSTRACT: To more concretely elucidate the long-term effects of chronic SSRI exposure during adulthood, the long-term consequences of chronic fluoxetine (12 mg/kg) versus vehicle treatment during adulthood (postnatal day (PND) 67-88) on gene expression in the hippocampus were investigated. The study showed that adult chronic fluoxetine exposure causes on the long-term changes in the expression of genes related to, amongst others, myelination Overall design: Comparison of gene expression in hippocampus tissue of fluoxetine and methylcellulose-exposed rats (postnatal day 128). 2 rats pooled per sample, 2 samples per treatment group

INSTRUMENT(S): Illumina Genome Analyzer IIx (Rattus norvegicus)

SUBMITTER: Jo Huiqing Zhou  

PROVIDER: GSE67203 | GEO | 2016-01-22

SECONDARY ACCESSION(S): PRJNA279259

REPOSITORIES: GEO

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GSE67203_Adult_Rat_Hippoc_Fluox_p0.05_FC1.5_diff_expr_transcripts.tsv.gz Tabular
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Publications

Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus.

Kroeze Y Y   Peeters D D   Boulle F F   Pawluski J L JL   van den Hove D L A DL   van Bokhoven H H   Zhou H H   Homberg J R JR  

Translational psychiatry 20150922


The selective serotonin reuptake inhibitor (SSRI) fluoxetine is widely prescribed for the treatment of symptoms related to a variety of psychiatric disorders. After chronic SSRI treatment, some symptoms remediate on the long term, but the underlying mechanisms are not yet well understood. Here we studied the long-term consequences (40 days after treatment) of chronic fluoxetine exposure on genome-wide gene expression. During the treatment period, we measured body weight; and 1 week after treatme  ...[more]

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