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C2C12 Myotubes in response to Palmitate

ABSTRACT: To identify mediators of obesity-linked reductions in PGC-1, we tested the effects of cellular nutrients in C2C12 myotubes. While overnight exposure to high insulin, glucose, glucosamine, or amino acids had no effect, saturated fatty acids (FA) potently reduced PGC-1a and b mRNA expression. Keywords: Nutrient Effect

ORGANISM(S): Mus musculus

PROVIDER: GSE6766 | GEO | 2007/01/18

SECONDARY ACCESSION(S): PRJNA98939

REPOSITORIES: GEO

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Transcription profiling of mouse C2C12 myotubes treated overnight with 500 uM palmitate or 1% bovine serum albumin control to identify mediators of obesity-linked reductions in PGC-1

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