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Transcriptomic analyses of duodenum from wild type and VDR-null mice

ABSTRACT: As duodenum is an important Vitamin D target organ, transcriptomic analyses were performed in this tissue.

ORGANISM(S): Mus musculus

PROVIDER: GSE67904 | GEO | 2015/04/16

SECONDARY ACCESSION(S): PRJNA281180

REPOSITORIES: GEO

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Transcriptomic analyses of duodenum from wild type and VDR-null mice

Project description:As duodenum is an important Vitamin D target organ, transcriptomic analyses were performed in this tissue. We analysed RNA extracted from duodenum of three 10 week-old wild-type and VDR-null mice using the Affymetrix Mouse Gene 2.0 ST.

2015-04-16 | E-GEOD-67904 | biostudies-arrayexpress

insulin resistant duodenum vs. non-insulin resistant duodenum

Project description:Transcriptional profiling of duodenum from non-obese patients and patients with morbid obesity comparing non-insulin resistance vs. insulin resistande. Goal was to determine the involvement of the duodenum in the development of insulin resistance and the possible influence of obesity.

2022-06-01 | GSE147562 | GEO

insulin resistant duodenum vs. non-insulin resistant duodenum

Project description:insulin resistant duodenum vs. non-insulin resistant duodenum

| PRJNA615363 | ENA

Expression in Duodenum of Wild type and Onecut-2 knockout mice at postnatal days 15 and 30

2010-07-07 | GSE18074 | GEO

Expression in Duodenum of Wild type and Onecut-2 knockout mice at postnatal days 15 and 30

Project description:Ablation of the mouse gene for Onecut-2 was reported previously, but characterization of the resulting knockout mice was focused on in utero development, principally embryonic development of liver and pancreas. Here, we examine postnatal development of these Onecut-2 knockout mice, especially the critical period prior to weaning. Microarray technology was used to determine the effect of Onecut-2 ablation on gene expression in duodenum, whose epithelium has among the highest levels of Onecut-2. A subset of intestinally expressed genes showed dramatically altered patterns of expression. Many of these genes encode proteins associated with the epithelial membrane, including many involved in transport and metabolism. Previously, we reported that Onecut-2 was critical to temporal regulation of the adenosine deaminase gene in duodenum. Many of the genes with altered patterns of expression in the Onecut-2 knockout mouse duodenum displayed changes in the timing of gene expression. Duodenal segments were isolated at postnatal days 15 and 30 from wild type 129 mice and 129 mice with the Onecut-2 gene ablated . Total RNA was isolated in biological triplicate for each experimental time point. Each triplicate contained RNA from 5-8 mice of the appropriate age and genotype. Affymetrix microarray technology was used to compare gene expression in wild type duodenum at d15 to gene expression in wild type duodenum at d30 and to compare gene expression in duodenum from Onecut-2 knockout mice at d15 and d30 to each other and to the expression in wild type duodenum.

2010-07-07 | E-GEOD-18074 | biostudies-arrayexpress

Rat duodenum during immobilization

Project description:In the present study, we examined duodenal gene expression in rats subjected to immobilization, to elucidate the mechanism of the stress response in the duodenum. Keywords: stress response

2007-03-09 | GSE4426 | GEO

miRNA profile of duck duodenum mucosa damage caused by oxidative stress

Project description:We deep sequenced and analyzed miRNAs using deep RNA sequencing (RNA-seq) in cage rearing and traditional breeding duck's duodenum sample of Nonghu NO.2 duck. 21 differentially expressed miRNA were identified in the duodenum. 6 miRNAs were upregulated and 15 were downregulated in the cage rearing duck's duodenum of the Nonghu NO.2 duck compared to their expression in the control group. These findings provided insights into the expression profiles of miRNAs in duck duodenum, and deepened our understanding of miRNAs in oxidative injury of duck.

2023-07-23 | GSE237634 | GEO

Genome-wide transcriptomic analysis of duodenum in broilers infused with crude Clostridium perfringens toxin in situ

Project description:We use a genome wide transcriptomic approach to assess the effects of C. perfringens toxin infusion in the duodenum of broilers

2015-05-31 | E-MTAB-1028 | biostudies-arrayexpress

RNA-seq in mouse duodenum

Project description:RNA-seq in mouse duodenum

| PRJNA595505 | ENA

Expression data from Chicken duodenum

Project description:The objective of this study was to decipher the molecular basis of feed efficiency in meat-type chicken using duodenum tissues from a chicken population divergently selected for residual feed intake (RFI). Residual feed intake is the deviation of expected feed intake from actual feed intake. Chickens that consume less feed than expected are efficient (LRFI) and chickens that consume more feed than expected are inefficient (HRFI). A divergent selection for RFI was undertaken using an unselected random bred chicken population. RFI at day 35-42 was used as a criterion for selecting low (LRFI) and high (HRFI) RFI. Duodenum tissues were collected from 16 male chickens under sterile conditions experimentation. Tissues were collected from 4 males at days 35 and 42 in each line. Duodenum at 35 and 42 days from a chicken population divergently selected for residual feed intake were utilized for RNA extraction and hybridization on Affymetrix microarrays.

2012-08-01 | E-GEOD-39824 | biostudies-arrayexpress

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