Transcriptomics

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Transcriptional profiling of antigen-specific CD8 T cells from wildtype and mutant mice.


ABSTRACT: To understand CD8 effector T cell differentiation in more detial we have used transcriptional profiling of antigen-specific CD8 T cells deficient in Blimp1, IL-2ra, or both, or Tbet. We reveal a common program of effector differentiation regulated by cytokine signaling and the combined activities of Blimp1 and T-bet, indicating remarkable redundancy and specificity in the control of genes involved in the differentiation of effector T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE68056 | GEO | 2016/03/07

SECONDARY ACCESSION(S): PRJNA281635

REPOSITORIES: GEO

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