TAF10 interacts with the GATA1 transcription factor and controls mouse erythropoiesis

ABSTRACT: We have ablated TAF10 in the erythroid compartment only by crossing the TAF10lox mice with the EpoR-Cre mice and we have studied the development of the erythroid cells in vivo. TAF10 ablation led to embryonic death at E13.5 while at E12.5 there was a clear developmental defect which was reflected in the transcriptional profile of the fetal liver cells. Gata1-target genes were mostly affected and were responsible for the lethal phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE68083 | GEO | 2015/04/21

SECONDARY ACCESSION(S): PRJNA281703

REPOSITORIES: GEO