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Characterization of deletions of the HBB locus by array comparative genomic hybridization

ABSTRACT: Array-CGH used to characterize HBB deletions causing beta thalassemia and HPFH

ORGANISM(S): Homo sapiens

PROVIDER: GSE68587 | GEO | 2015/05/06

SECONDARY ACCESSION(S): PRJNA283135

REPOSITORIES: GEO

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Characterization of deletions of the HBB locus by array comparative genomic hybridization

Project description:Array-CGH used to characterize HBB deletions causing beta thalassemia and HPFH Two-color experiment comparing thalssemia/HPFH subjects with normal DNA

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Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies

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The evolution of β-thalassemia major from minor is associated with paternal uniparental isodisomy of chromosome 11p15

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