Transcriptomics

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Accumulated α-synuclein affects the progression of GM2 gangliosidoses


ABSTRACT: The accumulation of α-synuclein (ASyn) has been observed in several lysosomal storage diseases (LSD), but it remains unclear if the accumulation of ASyn contributes to the pathology. The mitochondria degeneration, reduced expression of manganese superoxide dismutase 2, and reactive oxygen species-mediated oxidative damage were observed in the neurons of Hexb-/- mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE68748 | GEO | 2015/05/12

SECONDARY ACCESSION(S): PRJNA283813

REPOSITORIES: GEO

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