Genomics

Dataset Information

39

MLL1 and MLL fusion proteins play distinct roles in regulating MLLleukemic transcription program [ChIP-Seq]


ABSTRACT: This study describes the epigenetic profiling change of 1.) Mll1, WDR5 and H3K4me2 in mouse MAF9 leukemia cells treated with or without MM401; 2.) WDR5 and H3K4me2 epigenetic profiling in MLL1 flox/flox, ER-Cre+/- cells with knocking out MLL1 by 4OHT or not. Overall design: ChIP-Seq profile of Mll1, WDR5 and H3K4me2 were generated in MAF9 cells or MLL1 flox/flox, ER-cre+/- cells. A sequence profile of genomic DNA (Input) is also included.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

ORGANISM(S): Mus Musculus

SUBMITTER: Yali Dou  

PROVIDER: GSE68821 | GEO | 2016-05-12

SECONDARY ACCESSION(S): PRJNA283891

REPOSITORIES: GEO

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Publications

MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program.

Xu Jing J   Li Li L   Xiong Jie J   denDekker Aaron A   Ye Andrew A   Karatas Hacer H   Liu Liu L   Wang He H   Qin Zhaohui S ZS   Wang Shaomeng S   Dou Yali Y  

Cell discovery 20160517


Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global gene expression in MLLr cells, as well as its interplay with MLL1 fusion proteins remains unclear. Here we show that despite shared DNA-binding and cofactor interacting domains at the N terminus, MLL1 and MLL-AF9 are recruited to distinct chromatin regions and have divergent functions in regulating the leukemic transcri  ...[more]

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