Gene expression in IL-17RA-deficient and wild-type mice following Giardia muris infection

ABSTRACT: To elucidate IL-17A-dependent immune mechanims involved in regulating host defense, we employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential of regulating protective immunity that failed to be upregulated in the absence of IL-17RA signaling. Whole small intestine tissue collected from IL-17RA-deficient and C57BL/6 (wild-type) mice was collected 2 weeks after Giardia muris infection and from uninfected controls. Expression levels of several genes that may have anti-parasitic potential (Defb1, Retnlb, Saa1, Saa2) and may be involved in parasite clearance were, on average, lower or unchanged in IL-17RA deficient compared to wild-type mice after infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE68868 | GEO | 2015/05/15

SECONDARY ACCESSION(S): PRJNA283945

REPOSITORIES: GEO