Parkin-mediated mitophagy evokes perinatal cardiac mitochondria maturation

ABSTRACT: Exclusion of Parkin from mitochondria of perinatal cardiomyocytes interrupts structural and molecular transformations essential to normal perinatal-adult mitochondrial replacement. mRNA-sequencing from cardiac total RNA was performed at P1, P21 and 5-week stages of nontransgenic (ntg) and human-Mfn2-overexpressing (Mfn2wt) hearts, and also of tet-off control (tetoff) and human-Mfn2 T111A/S442A-overexpressing (Mfn2AA) hearts.

ORGANISM(S): Mus musculus

PROVIDER: GSE68921 | GEO | 2015/12/04

SECONDARY ACCESSION(S): PRJNA284112

REPOSITORIES: GEO