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Genome-wide analysis of ATF4 binding in histidinol-treated cells and RNA-Seq experiment to identify genes regulated by ATF4

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE69309 | GEO | 2015/08/28

SECONDARY ACCESSION(S): PRJNA285115

REPOSITORIES: GEO

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Genome-wide analysis of ATF4 binding in histidinol-treated cells and RNA-Seq experiment to identify genes regulated by ATF4

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-08-28 | E-GEOD-69309 | biostudies-arrayexpress

RNA-Seq experiment to identify genes regulated by ATF4

2015-08-28 | GSE69308 | GEO

RNA-Seq experiment to identify genes regulated by ATF4

Project description:Activating Transcription Factor 4 (ATF4) is a transcription factor induced by the integrated stress response (ISR). This experiment is a genome-wide profiling of ATF4-dependent RNA expression in human HAP-1 cells. HAP-1 is a near-haploid human cell line that was derived from KBM-7 cells isolated from a patient with Chronic Myelogenous Leukemia. We analyzed WT and ATF4 KO cells. We induced ATF4 expression by mimicking amino acid starvation with the drug histidinol. RNA expression profiles were generated for WT and ATF4 KO HAP1 cells. ATF4 genes were mutated using Cas9 genome editing technology. Amino acid starvation was mimicked by treating WT and ATF4 KO cells with 2 mM histidinol for 24 hours, which increases ATF4 expression.

2015-08-28 | E-GEOD-69308 | biostudies-arrayexpress

Genome-wide analysis of ATF4 binding in histidinol-treated cells and RNA-Seq experiment to identify genes regulated by ATF4

Project description:Genome-wide analysis of ATF4 binding in histidinol-treated cells and RNA-Seq experiment to identify genes regulated by ATF4

| PRJNA285115 | ENA

Genome-wide analysis of ATF4 binding in histidinol-treated cells

2015-08-28 | GSE69304 | GEO

Genome-wide analysis of ATF4 binding in histidinol-treated cells

Project description:Activating Transcription Factor 4 (ATF4) is a transcription factor induced by the integrated stress response (ISR). This experiment is a genome-wide occupancy profiling of ATF4 in human HAP1 cells. HAP1 is a near-haploid human cell line that was derived from KBM-7 cells isolated from a patient with Chronic Myelogenous Leukemia. We induced ATF4 expression by mimicking amino acid starvation with the drug histidinol. We identified peaks of ATF4 binding using three independent antibodies. Examination of ATF4 binding in HAP1 cells treated with 2 mM histidinol for 24 hours.

2015-08-28 | E-GEOD-69304 | biostudies-arrayexpress

Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins.

Project description: Not available

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Genome-wide analysis of HOXC4 and HOXC6 regulated genes and binding sites in prostate cancer cells.

Project description: Not available

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Genome-wide characterization of light-regulated genes in Neurospora crassa.

Project description: Not available

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Genome-wide studies identify genes directly regulated by PML/RARα fusion protein

Project description:Acute promyelocytic leukemia (APL) is characterized by a specific t(15;17) chromosome translocation that generates the promyelocytic leukemia/retinoic acid receptor-α (PML/RARα) fusion gene. However, the global association between PML/RARα and transcriptional co-regulators, and the rules of their association in governing the key processes during the leukemogenesis remain obscure. Here, we performed the genome-wide binding profiling of PML/RARα, HDAC1 and P300, in NB4, an APL patient-derived cell line. We found that PML/RARα targets could be classified into two classes. Moreover, we also performed ChIP-seq of H3K27ac to determine super-enhancers in NB4. We identified a novel function of PML/RARα in super-enhancer regulation during the leukemogenesis of APL.

2020-08-26 | GSE126720 | GEO

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