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Expression data from pre-B ALL tumors isolated from ingeneered mice from the indicated genotypes

ABSTRACT: The Ink4a/Arf tumor supressors play crucial roles in inhibiting cell cycle progression at the G1/S checkpoint. Activating mutations in the KrasG12D oncogene is one of the most frequent changes in human cancer, with resultant constitutive mitogenic signaling within the cell. We generated cohorts of CD19Cre; KrasG12D/+; Ink4a/ArfL/+ mice to evaluate the combined contributions of Ink/Arf loss and KrasG12D activation in pre-B ALL lymphomas. In this data set we include the expression data obtained from pre-B ALL lymphomas isolated from mice with simultaneous deletion of the Ink/Arf locus and activation of KrasG12D oncogene (and CD19Cre; KrasG12D/+; Ink4a/ArfL/+ mice).

ORGANISM(S): Mus musculus

PROVIDER: GSE69368 | GEO | 2015/05/30

SECONDARY ACCESSION(S): PRJNA285320

REPOSITORIES: GEO

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