Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Development of gene expression for an INH-responsive transcriptional regulator InbR

ABSTRACT: To further determine the gene expression profile of InbR, encoded by Rv0275c in Mycobacterium tuberculosis, whole genome microarray analysises were applied to inbR-overexpressing strain and wild type Mycobacterium bovis BCG. Comparison of the gene expression pattern of logarithmic growth phase wild-type M. bovis BCG and that of the inbR-overexpression strain revealed a total of 142 genes that were significantly up-regulated (2-fold to 187-fold, p < 0.05) and 200 that were down-regulated (2-fold to 113-fold, p < 0.05). Strikingly, most of the genes in the regulon were predicted to function as molecular chaperones, heat shock proteins, or transcription factors.

ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2

PROVIDER: GSE69379 | GEO | 2015/05/30

SECONDARY ACCESSION(S): PRJNA285333

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Microarray Analysis of Toxicogenomic Effects of Triclosan on Mycobacterium bovis BCG

Project description:Global gene expression analysis of Mycobacterium bovis BCG following Triclosan treatment using Affymetrix GeneChip arrays. Results from this study provide insight into the molecular mechanisms underlying the cellular response of Mycobacterium bovis BCG to Triclosan We conducted three independent microarray experiments (biological replicates) in the absence (control) and the presence (experimental) of triclosan. Fold change was calculated as a ration between the signal averages of three untreated (control) and three triclosan-treated (experimental) cultures for 0, 10 and 60min exposures.

2012-12-25 | E-GEOD-33800 | biostudies-arrayexpress

Genome-wide profiling of miRNA expression dynamics in monocyte-derived dendritic cells following infection with a panel of intra-cellular bacteria

Project description:We report the application of RNA sequencing to assess the expression dynamics of miRNAs and their isoforms over time upon infection with a panel of six intracellular bacteria (Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis Beijing strain GC1237, Mycobacterium bovis BCG, Salmonella typhimurium strain Keller, Staphloccocus epidermidis and Yersinia pseudotuberculosis)

2015-02-18 | GSE64142 | GEO

Microarray Analysis of Toxicogenomic Effects of Triclosan on Mycobacterium bovis BCG

2012-12-25 | GSE33800 | GEO

Microarray Analysis of Toxicogenomic Effects of Hydrogen Peroxide on Mycobacterium bovis BCG

Project description:In the present study, we employed Affymetrix Mycobacterium bovis BCG GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Mycobacterium bovis BCG to hydrogen peroxide, which involved initial growth inhibition and metabolism. Keywords: Transcriptome study We conducted three independent microarray experiments (biological replicates) in the absence (control) and the presence (experimental) of hydrogen peroxide. We calculated fold change as the ratio between the signal averages of three untreated (control) and three hydrogen peroxide-treated (experimental) cultures for 0, 10 and 60 min exposures.

2010-05-06 | E-GEOD-14272 | biostudies-arrayexpress

Microarray Analysis of Toxicogenomic Effects of Sodium Hypochlorite on Mycobacterium bovis BCG

Project description:In the present study, we employed Affymetrix Mycobacterium bovis BCG GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Mycobacterium bovis BCG to Sodium Hypochlorite, which involved initial growth inhibition and metabolism. Keywords: Transcriptome study We conducted three independent microarray experiments (biological replicates) in the absence (control) and the presence (experimental) of Sodium Hypochlorite. We calculated fold change as the ratio between the signal averages of three untreated (control) and three Sodium Hypochlorite-treated (experimental) cultures for 0, 10 and 20 min exposures.

2010-05-15 | E-GEOD-13423 | biostudies-arrayexpress

Toxicogenomic response of Mycobacterium bovis to disinfectant treatments

Project description:This SuperSeries is composed of the following subset Series: GSE13423: Microarray Analysis of Toxicogenomic Effects of Sodium Hypochlorite on Mycobacterium bovis BCG GSE14272: Microarray Analysis of Toxicogenomic Effects of Hydrogen Peroxide on Mycobacterium bovis BCG Refer to individual Series

2009-01-19 | E-GEOD-14349 | biostudies-arrayexpress

Microarray Analysis of Toxicogenomic Effects of Hydrogen Peroxide on Mycobacterium bovis BCG

2009-01-20 | GSE14272 | GEO

Microarray Analysis of Toxicogenomic Effects of Sodium Hypochlorite on Mycobacterium bovis BCG

2008-12-01 | GSE13423 | GEO

Microarray Analysis of Toxicogenomic Effects of peracetic acid on Mycobacterium bovis BCG

2009-03-31 | GSE15023 | GEO

Genome-wide profiling of miRNA expression dynamics in monocyte-derived dendritic cells following infection with a panel of intra-cellular bacteria

2015-02-18 | E-GEOD-64142 | biostudies-arrayexpress