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Selective glucocorticoid-induced attenuation of the inflammatory response in zebrafish

ABSTRACT: In the present study, we have used the zebrafish to investigate the anti-inflammatory effects of glucocorticoids. An inflammatory response was induced by amputation of the tail fin of 3dpf zebrafish larvae, and the effect of treatment with the glucocorticoid beclomethasone was investigated. A microarray study was performed to study transcriptional changes 4 hours after amputation and the beclomethasone-induced effects on these changes. Our results show that beclomethasone attenuates almost the entire transcriptional response to amputation. Interestingly, the amputation-induced expression of genes involved in leukotriene biosynthesis appears to be resistant to beclomethasone treatment.

ORGANISM(S): Danio rerio

PROVIDER: GSE69444 | GEO | 2015/12/01

SECONDARY ACCESSION(S): PRJNA285499

REPOSITORIES: GEO

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