Crohn's disease risk variant in GPR65 alters lysosomal function

ABSTRACT: Using an siRNA screen we identify a role for GPR65 in the defense against intracellular pathogens. Epithelial cells and macrophages lacking GPR65 exhibited impaired clearance of intracellular bacteria as well as an accumulation of aberrant phagosomes and lysosomes. Transcriptional profiling revealed changes in genes associated with lysosomal function.

ORGANISM(S): Mus musculus

PROVIDER: GSE69445 | GEO | 2016/06/15

SECONDARY ACCESSION(S): PRJNA285503

REPOSITORIES: GEO