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Expression profiling of T.rubrum treated with Terbinafine

ABSTRACT: One antifungal agent, terbinafine(TRB), has specific activity against dermatophytes.A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to TRB were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: original article

ORGANISM(S): Trichophyton rubrum

PROVIDER: GSE6951 | GEO | 2008/02/04

SECONDARY ACCESSION(S): PRJNA99343

REPOSITORIES: GEO

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Expression profiling of T.rubrum treated with Terbinafine

Project description:One antifungal agent, terbinafine(TRB), has specific activity against dermatophytes.A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to TRB were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: original article The expression profiles of Trichophyton rubrum treated with TRB were compared to those of Trichophyton rubrum without drug. Each treatment has three replicates.

2010-06-26 | E-GEOD-6951 | biostudies-arrayexpress

Expression profiling of T. rubrum treated with amphotericin B and ketoconazole

Project description:Two antifungal agents, ketoconazole (KTZ) and amphotericin B (AMB), have specific activity against dermatophytes.A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to KTZ and AMB were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: comparison of expression status

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Global transcription profiles of Trichophyton rubrum in response to Flucytosine

2008-09-23 | GSE12861 | GEO

Expression profiling of T.rubrum treated with PH11B

Project description:T. rubrum was treated with PH11B,a potent eucaryotic fatty acid synthase inhibtor. A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to PH11B were determined. Some class-specific and mechanism-independent changes in gene expression were found. Keywords: fatty acid synthase inhibition

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Transcriptional profiles of T.rubrum treated with PHS11A

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Transcriptome profile of T. mentagrophytes exposed to different drugs

Project description:Dermatophytosis is a common and relevant zoonotic disease of public health concern, Various antifungal compounds, including clotrimazole, terbinafine, and ketoconazole have been reported for the treatment of dermatophytosis,In the present study,Transcriptome profile of T. mentagrophytes exposed to different drugs was performed in order to find the important drug antifungal active point.

2021-04-13 | GSE162331 | GEO

Expression profiling of T.rubrum treated with PH11B

2007-11-21 | E-GEOD-6336 | biostudies-arrayexpress

Antifungal activity of the repurposed drug disulfiram against Cryptococcus neoformans.

Project description:Fungal infections have become a clinical challenge due to the emergence of drug-resistance of invasive fungi and a rapid increase of novel pathogens. The development of drug resistance has further restricted the use of antifungal agents. Therefore, there is anurgentneedto searchforalternativetreatmentoptions for Cryptococcus neoformans (C. neoformans). Disulfiram (DSF) has a high human safety profile and promising applications as an antiviral, antifungal, antiparasitic, and anticancer agent. In contrast, the effect of DSF on Cryptococcus has yet to be thoroughly researched. This study investigated the antifungal effect and mechanism of DSF againstC. neoformansto provide a new theoretical foundation for treating Cryptococcal infections. In vitro studies demonstrated that DSF inhibitedCryptococcusat minimum inhibitory concentrations (MICs) ranging from 1.0 to 8.0 μg/mL. Combined antifungal effects were also observed with 5-fluorocytosine, amphotericin B, terbinafine, or ketoconazole. In vivo, DSF exerted asignificantprotectiveeffectforGalleria mellonella infected with C. neoformans.Mechanistic investigations showed that DSF dose-dependently inhibited the melanin, urease, acetaldehyde dehydrogenase, capsule, and biofilm formation or viability ofC. neoformans.Further study indicated DSF affectedC. neoformansby interfering with multiple biological pathways, including replication, metabolism, membrane transport, and biological enzyme activity. Potentially essential targets of these pathways included acetaldehyde dehydrogenase, catalase, ATP-binding cassette transporter (ABC transporter) AFR2, and iron-sulfur cluster transporter ATM1. These findings contribute to the understanding of mechanisms inC. neoformans, and provide new insights for the application of DSF.

2023-12-31 | GSE248987 | GEO

Transcriptional profiles of T.rubrum treated with PHS11A

Project description:A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to PHS11A, a fatty acid synthase inhibitor, were determined. The expression profiles of Trichophyton rubrum treated with PHS11A were compared to those of Trichophyton rubrum without drug. Each treatment has three replicates.

2010-06-25 | E-GEOD-6403 | biostudies-arrayexpress

Global transcription profiles of Trichophyton rubrum in response to Flucytosine

Project description:A cDNA microarray was constructed from the expressed sequence tags (ESTs) of different developmental stages, and transcriptional profiles of the responses to 5-Flucytosine were determined. Keywords: Expression profiling by array The expression profiles of Trichophyton rubrum treated with 5-Flucytosine were compared to those of Trichophyton rubrum without drug. Each treatment has three replicates.

2010-05-19 | E-GEOD-12861 | biostudies-arrayexpress

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