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Gene expression analysis of WT, HBZ-Tg, IFNgKO, and HBZ-Tg/IFNg KO mice.

ABSTRACT: Comprehensive analysis of gene expression in CD4+ T cells of WT, HBZ-Tg, IFNgKO, and HBZ-Tg/IFNg KO mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE69804 | GEO | 2015/08/25

SECONDARY ACCESSION(S): PRJNA286843

REPOSITORIES: GEO

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Gene expression analysis of WT, HBZ-Tg, IFNgKO, and HBZ-Tg/IFNg KO mice.

Project description:Comprehensive analysis of gene expression in CD4+ T cells of WT, HBZ-Tg, IFNgKO, and HBZ-Tg/IFNg KO mice. CD4+ T cells were isolated from splenocytes of each strain. From isolated CD4+ T cells, RNAs were extracted and used for microarray analysis.

2015-08-25 | E-GEOD-69804 | biostudies-arrayexpress

Mus musculus

Project description:Gene expression analysis of WT, HBZ-Tg, IFNgKO, and HBZ-Tg/IFNg KO mice.

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Comparing the difference in gene expression between TDAG51 WT vs TDAG51 KO, and TDAG51 KO Tg vs TDAG51 KO

Project description:Transcriptional profiling of postpartum day 0 mouse brain, comparing TDAG51 wild-type (WT) vs TDAG51 knockout (KO), and TDAG51 KO transgenic (Tg) vs TDAG51 KO.

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The effect of HTLV-1 bZIP factor (HBZ) RNA and protein in mouse CD4 T cells

Project description:Human T-cell leukemia virus type 1 (HTLV-1) bZIP factor (HBZ) which is encoded in the minus strand of HTLV-1 provirus, possesses dual function as protein, and also as RNA. To know the effect of HBZ RNA and protein in primary T-cells, we introduced HBZ, or its mutant TTG (exclude protein activity), or SM (exclude RNA activity) with retrovirus vector into CD4 positive murine T cells, and analysed the transcriptome profiling. We found that HBZ RNA altered cell cycle progression, cell survival related genes, while HBZ protein altered immunology related genes. This microarray results demonstrated that HBZ RNA and protein possess distinct functions in primary cells. CD4 positive cells were enriched from murine splenocyte, and cultured with irradiated antigen presenting cells (APC). HBZ, or its mutant were introduced with retroviral vector. Forty eight hours after introduction, cells were washed and cultured with recombinant human IL-2. Further 48 hours after culture, virus infected cells were sorted and analysed by agilent microarray.

2016-04-01 | E-GEOD-70649 | biostudies-arrayexpress

The effect of HTLV-1 bZIP factor (HBZ) RNA and protein in mouse CD4 T cells

2016-04-01 | GSE70649 | GEO

Expression data from CD71+ cells from the bone marrow of WT, CD70TG, IFNg-/- and CD70TG*IFNg-/- mice.

Project description:CD70TG mice are a model for sterile chronic immune activation and develop Anemia of Inflammation, which is dependent on the production of Ifng by effector CD4 and CD8 T cells. We used microarrays to identify Ifng-dependent differentially expressed genes that could account for the erythropoietic defect. CD71+ cells were MACS-enriched from the bone marrow of WT, CD70TG, IFNg-/- and CD70TG*IFNg-/- male mice of 10-12 weeks of age (3 mice per genotype group).

2011-07-31 | E-GEOD-22656 | biostudies-arrayexpress

Expression data from CD71+ cells from the bone marrow of WT, CD70TG, IFNg-/- and CD70TG*IFNg-/- mice.

2011-08-01 | GSE22656 | GEO

Expression data of Jurkat cells stably expressing HBZ with or without stimulation

Project description:Human T-cell leukemia virus type 1 (HTLV-1) encodes HTLV-1 bZIP factor (HBZ), which is thought to be crucial for neoplastic and inflammatory diseases caused by HTLV-1. So, we analyzed the transcriptional profile of HBZ expressing cells and how HBZ affect the expression of apoptosis-related genes. We used microarrays to detail the effect of HTLV-1 bZIP factor (HBZ), which is encoded in the minus strand of HTLV-1 genome on gene expression. Especially how HBZ affect the expression of apoptosis-related genes. Jurkat cells stably expressing HBZ were stimulated with or without PMA and ionomycin for 9hours. Then RNA extraction and hybridization on Affymetrix microarrays were performed.

2013-06-18 | E-GEOD-48029 | biostudies-arrayexpress

mRNAseq and proteomic data set of one week old WT (Chop wt/wt CkmmCre wt/wt Dars2 fl/fl), Chop KO (Chop ko/ko CkmmCre wt/wt Dars2 fl/fl), Dars2 KO (Chop wt/wt CkmmCre tg/wt Dars2 fl/fl) and DKO (Chop ko/ko CkmmCre tg/wt Dars2 fl/fl) mice

Project description:mRNAseq and proteomic data set of one week old WT (Chop wt/wt CkmmCre wt/wt Dars2 fl/fl), Chop KO (Chop ko/ko CkmmCre wt/wt Dars2 fl/fl), Dars2 KO (Chop wt/wt CkmmCre tg/wt Dars2 fl/fl) and DKO (Chop ko/ko CkmmCre tg/wt Dars2 fl/fl) mice

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Expression data of Jurkat cells stably expressing HBZ with or without stimulation

2013-06-18 | GSE48029 | GEO

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