Transcriptomics,Genomics

Dataset Information

21

Gene expression profile of mouse CD206+F4/80+CD11b+ M2-like macrophages


ABSTRACT: Characterisation of M2-like macrophage in terms of gene expression level. The hypothesis tested in the present study was that M2-like macrophages in myocardial infarction (MI) heart have upregulation of genes relevant to cardiac repair. The results obtained showed tha various tanti-inflammatory and reparative genes were upregulated in M2-like macrophage from MI heart compared to those from intact hearts. M2-like macrophages from the heart (either MI or intact) were distinct from those in the peritoneal cavity. Overall design: Total RNA obtained from M2-like macrophages from peritoneal cavity, intact heart and myocardial infarction heart.

INSTRUMENT(S): Illumina MouseWG-6 v2.0 expression beadchip

SUBMITTER: KEN SUZUKI   

PROVIDER: GSE69879 | GEO | 2017-06-14

SECONDARY ACCESSION(S): PRJNA287018

REPOSITORIES: GEO

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Publications

Alternatively activated macrophages determine repair of the infarcted adult murine heart.

Shiraishi Manabu M   Shintani Yasunori Y   Shintani Yusuke Y   Ishida Hidekazu H   Saba Rie R   Yamaguchi Atsushi A   Adachi Hideo H   Yashiro Kenta K   Suzuki Ken K  

The Journal of clinical investigation 20160503 6


Alternatively activated (also known as M2) macrophages are involved in the repair of various types of organs. However, the contribution of M2 macrophages to cardiac repair after myocardial infarction (MI) remains to be fully characterized. Here, we identified CD206+F4/80+CD11b+ M2-like macrophages in the murine heart and demonstrated that this cell population predominantly increases in the infarct area and exhibits strengthened reparative abilities after MI. We evaluated mice lacking the kinase  ...[more]

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