Genomics

Dataset Information

61

Genome-wide analysis of gene expression in the cervical spinal cord of a mouse model of atopic dermatitis


ABSTRACT: Genome-wide analysis of gene expression in the cervical spinal cord of atopic dermatitis model mice was performed. Results provide important information for understanding of molecular mechanisms of the symptoms of atopic dermatitis. Overall design: Total RNA was odtained from the cervical spinal cord of normal or atopic dermatitis model mice.

INSTRUMENT(S): Illumina MouseWG-6 v2.0 expression beadchip

SUBMITTER: Miho Shiratori-Hayashi  

PROVIDER: GSE70114 | GEO | 2015-07-17

SECONDARY ACCESSION(S): PRJNA287660

REPOSITORIES: GEO

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Publications


Chronic itch is an intractable symptom of inflammatory skin diseases, such as atopic and contact dermatitis. Recent studies have revealed neuronal pathways selective for itch, but the mechanisms by which itch turns into a pathological chronic state are poorly understood. Using mouse models of atopic and contact dermatitis, we demonstrate a long-term reactive state of astrocytes in the dorsal horn of the spinal segments that corresponds to lesioned, itchy skin. We found that reactive astrogliosis  ...[more]

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