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The epigenetic and transcriptional basis of the developmental transition from brown to white adipose tissue

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Ovis aries

PROVIDER: GSE70266 | GEO | 2019/07/01

REPOSITORIES: GEO

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The epigenetic and transcriptional basis of a developmental transition from brown to white adipose tissue

Project description:Brown and white adipose tissues are functionally and morphologically distinct. Theformer tissue has a primary role in maintaining thermogenesis in new born mammals while the latter acts as an energy storage vehicle that enhances survival when food is limiting. Both tissues are involved in maintaining energy homeostasis in adults and are strongly implicated in chronic metabolic diseases associated with obesity in humans. The perirenal adipose depot in sheep undergoes a relatively rapid transition from brown to white adipose tissue between late gestation and a few weeks after birth. However, little is known about this developmental process in terms of mechanism, changes in gene expression and epigenetic architecture. Citation: Tony Vuocolo, Aaron Statham, Denis C. Bauer, Sean McWilliam, Shalima Nair, Janna L Morrison, Song Zhang, Michael Buckley, Isabella C McMillen, Susan Clark, Ross L Tellam. "The epigenetic and transcriptional basis of the developmental transition from brown to white adipose tissue" ( submitted).

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