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Profiling of Rgt1-regulated gene transcripts (30º C) in the fungal pathogen Candida albicans

ABSTRACT: C. albicans glucose sensing and signaling is important for full virulence in the mammalian host. To better understand this phenomenon, we investigated the Hgt4 glucose-sensing pathway, focusing on the downstream transcriptional repressor CaRgt1. CaRgt1-regulated gene transcripts were identified by comparing total RNA extracted from wild type and rgt1 mutant strains. Cells were grown at 30 degrees C in the presence of glycerol, conditions under which CaRgt1 was expected to repress gene transcription. Keywords: cell type comparison

ORGANISM(S): Candida albicans

PROVIDER: GSE7043 | GEO | 2007/03/01

SECONDARY ACCESSION(S): PRJNA104039

REPOSITORIES: GEO

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Profiling of Rgt1-regulated gene transcripts (37º C) in the fungal pathogen Candida albicans

Project description:C. albicans glucose sensing and signaling is important for full virulence in the mammalian host. To better understand this phenomenon, we investigated the Hgt4 glucose-sensing pathway, focusing on the downstream transcriptional repressor CaRgt1. CaRgt1-regulated gene transcripts were identified by comparing total RNA extracted from wild type and rgt1 mutant strains. Cells were grown at 37 degrees C in the presence of glycerol, conditions under which CaRgt1 was expected to repress gene transcription. Keywords: cell type comparison

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