Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An integrative map of transcriptional responses to exercise in non-muscle organs

ABSTRACT: Global gene expression was measured with Affymetrix in seven organs after 3 weeks swimming and control (non swimming) C57BL6 male mice, 14wks old ( by the end of the study). We used microarrays to detail the global programme of gene expression indicative of adaptatie changes occuring in seven tissues, skeletal muscle (quadricepts), liver, kidney, subcutaneous and visceral white adipose tissues, spleen, brain, after 3 weeks of swimming

ORGANISM(S): Mus musculus

PROVIDER: GSE70655 | GEO | 2021/09/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Whole transcriptome analysis of diaphragms from FKRPP448L-NSG and NSG mice induced by swimming exercise

Project description:Muscle pre-injury is commonly used prior to cell transplantation to enhance engraftment and to further promote homing of injected cells to diseased muscles. To better understand the changes that occurred in the diaphragm upon swimming (1hour/day for 2 weeks), we analyzed global changes using RNA-Seq in dystrophic FKRPP448L-NSG mice as well as in NSG control mice.

2017-06-01 | GSE82164 | GEO

Exercise training effects on disease resistance are dependent on training regimes and inherent swimming performance in Atlantic salmon

2012-06-09 | GSE38603 | GEO

Sequencing of Nothobranchius fuzeri muscle (strain: GRZ) after physical exercise

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: GRZ) muscle after physical exercise. For physical exercise, fish were placed in swim-tunnel for 4 weeks and were swimming 6 times per day for 5 min duration (water velocity 14 cm/s). The RNA-seq data comprise 10 samples. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103815 | GEO

Sequencing of Nothobranchius fuzeri (strain: GRZ) liver after physical exercise

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: GRZ) liver after physical exercise. For physical exercise, fish were placed in swim-tunnel for 4 weeks and were swimming 6 times per day for 5 min duration (water velocity 14 cm/s). The RNA-seq data comprise 10 samples. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103808 | GEO

Sequencing of Nothobranchius fuzeri (strain: GRZ) brain after physical exercise

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: GRZ) brain after physical exercise. For physical exercise, fish were placed in swim-tunnel for 4 weeks and were swimming 6 times per day for 5 min duration (water velocity 14 cm/s). The RNA-seq data comprise 10 samples. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103803 | GEO

Sequencing of Nothobranchius fuzeri (strain: GRZ) skin after physical exercise

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: GRZ) skin after physical exercise. For physical exercise, fish were placed in swim-tunnel for 4 weeks and were swimming 6 times per day for 5 min duration (water velocity 14 cm/s). The RNA-seq data comprise 10 samples. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103818 | GEO

Exercise training effects on disease resistance are dependent on training regimes and inherent swimming performance in Atlantic salmon

Project description:Atlantic salmon juveniles were screened for swimming performance and separated into either poor or good swimmers. After ten weeks of rearing in fresh water, during which both swimming performance groups were part of an exercise training experiment, fish were transferred to seawater and challenged with infectious pancreatic necrosis virus (IPNV) in a co-habitation test. When mortality curve levelled out (45 days post commencement of challenge test), fish that had previously been categorized as good swimmers displayed a significantly higher survival (86.1%) compared to poor swimmers (77.6%). Global gene expression analyses were performed to search for disease resistance correlates. Cardiac ventricle expression of 21 genes was greater in poor swimmers than in good swimmers. These genes were previously classified as virus-responsive genes (VRGs), being reliable markers of viral load. This suggested that inherent swimming performance is associated with higher disease resistance. Atlantic salmon post-smolts belonging to groups previously classified as either poor or good swimmers were challenged with infectious pancreatic necrosis virus (IPNV). Heart ventricle was sampled from challenged and unchallenged fish on day 45 post-commencement of the challenge (when no more mortalities were registered). Nine poor swimmers and nine good swimmers were hybridized against a common reference sample composed of nine unchallenged fish.

2012-06-08 | E-GEOD-38603 | biostudies-arrayexpress

Global gene expression profiles and the progression of pro- and anti-inflammatory pathways in mouse models

Project description:Gaucher Disease (GD) is caused by defective glucocerebrosidase (GCase) activity and the consequent accumulation of its substrate, glucosylceramide (GC). This excess of accumulation of GC leads to broad functional impairments in multiple organs, but the pathogenic pathways leading to lipid laden macrophages (Gaucher cells) in visceral organs and their abnormal function is obscure. To understand the molecular pathogenesis of GD, developmental global gene expression was conducted by microarray analyses of total mRNAs from lung and liver of two distinct GCase point-mutated mice (V394L/V394L and D409V/null) and genetic background matched wild-type controls. INFg regulated pro-inflammatory and IL-4 regulated anti-inflammatory cytokine/mediator network were constructed in the lung and liver of GCase mutant mice. Progressive alterations of the INFg and IL-4 pathways were similar, but to different degrees, in visceral tissues from the two different GCase mutated mice. These analyses implicate IFNg regulated pro-inflammatory and IL-4 regulated anti-inflammatory networks in the differential pathophysiological progression. In order to understand the molecular pathogenesis of GD, the disease progression in those models were inverstigated in two visceral tissues (lung and liver) at four time points according to the genotypes. 9V/null: 4 weeks (4w), 12 weeks (12w), 18 weeks (18w), 28 weeks (28w); 4L: weeks (4w), 12 weeks (12w), 18 weeks (18w), 28 weeks (28w). The data from those models were analyzed relative to the adult wild type at 28 weeks.

2011-08-01 | E-GEOD-23408 | biostudies-arrayexpress

Sequencing of Nothobranchius furzeri (strain: MZM-04/10p) muscle after physical exercise in 2 age groups

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: MZM-04/10p) muscle for 2 age groups after physical exercise (swim-tunnel). For physical exercise, fish were placed in swim-tunnel for 4 weeks and were swimming 6 times per day for 5 min duration (water velocity 14 cm/s). The RNA-seq data comprise 3 groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103816 | GEO

Sequencing of Nothobranchius furzeri (strain: MZM-04/10p) brain after physical exercise in 2 age groups

Project description:Comparison of gene expression profiles from Nothobranchius furzeri (strain: MZM-04/10p) brain for 2 age groups after physical exercise (swim-tunnel). For physical exercise, fish were placed in swim-tunnel for 4 weeks and were swimming 6 times per day for 5 min duration (water velocity 14 cm/s). The RNA-seq data comprise 3 groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE103806 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data