Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Sschwann Cells after 72 h

ABSTRACT: The aim of this study was to identify differently expressed genes between C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells. To elucidate the unresolved mechanism behind the promoting effect of C3156-181 on PNR we cultured primary rat neonatal SCs and treated them for up to 72 h with C3 or C3156-181. We then performed gene expression microarray analysis Results from two loops of two different treatment times are summarized in this study. The samples were taken from two C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cell cultures. Microarrays were hybriszed in a loop approach.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE70748 | GEO | 2015/07/11

SECONDARY ACCESSION(S): PRJNA289485

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Comparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells after 12 h

2015-07-11 | GSE70747 | GEO

Comparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells after 12 h

Project description:The aim of this study was to identify differently expressed genes between C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells. To elucidate the unresolved mechanism behind the promoting effect of C3156-181 on PNR we cultured primary rat neonatal SCs and treated them for up to 72 h with C3 or C3156-181. We then performed gene expression microarray analysis Results from two loops of two different treatment times are summarized in this study. The samples were taken from two C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cell cultures. Microarrays were hybridized in a loop approach. Results from two loops that map to two different sampling times (loop1: after 12 hours, loop2: after 72) are compared in this study. The data in this file represents loop1. The samples were taken from untreated, C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells.

2015-07-11 | E-GEOD-70747 | biostudies-arrayexpress

Comparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Sschwann Cells after 72 h

Project description:The aim of this study was to identify differently expressed genes between C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells. To elucidate the unresolved mechanism behind the promoting effect of C3156-181 on PNR we cultured primary rat neonatal SCs and treated them for up to 72 h with C3 or C3156-181. We then performed gene expression microarray analysis Results from two loops of two different treatment times are summarized in this study. The samples were taken from two C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cell cultures. Microarrays were hybriszed in a loop approach. Results from two loops that map to two different sampling times (loop1: after 12 hours, loop2: after 72) are compared in this study. The data in this file represents loop2. The samples were taken from The samples were taken from untreated, C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells.

2015-07-11 | E-GEOD-70748 | biostudies-arrayexpress

Project description:Comparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells

| PRJNA289482 | ENA

Rattus norvegicus

Project description:Comparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells after 12 h

| PRJNA289484 | ENA

Rattus norvegicus

Project description:Comparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Sschwann Cells after 72 h

| PRJNA289485 | ENA

Algesic MBP peptide induce pain-specific signaling in rodent Schwann Cells

Project description:We demonstrated the pain-specific response to the algesic peptide fragment MBP84-104 of myelin basic protein that induces pain if injected into sciatic nerve of rats and mice. We used the wild-type peptide MBP 84-104, H89G mutant peptide (MBP84-104-H89G), scramble peptide (MBP84-104-SCR) and phosphomimetic peptide MBP84-104-mimTT to stimulate the primary rat Schwann cell cultures. After 24h we isolated total RNA and conducted genome wide RNA-seq. In addition, we performed RNA-seq using Schwann cells constitutively expressing an MBP84-104-mCherry construct. The gene expression data was analyzed using Ingenuity Pathway Analysis software. We conclude that the Schwann cells expressing MBP84-104 constructs stimulate pain-specific signaling pathways thus representing a relevant model to study neuropathic pain.

2018-08-13 | GSE107020 | GEO

Transcription profiling of rat neonatal ventricular cardiac mycocytes exposed to endothelin-1 and C3 toxin

Project description:Effects of C3 toxin on RNA profiles in neonatal rat ventricular cardiac myocytes exposed to endothelin-1 (1 h)

2010-05-25 | E-MEXP-1977 | biostudies-arrayexpress

miR-181 regulates colonic inflammation

Project description:The intestinal epithelium is a key physical interface that integrates dietary and microbial signals to regulate nutrient uptake and mucosal homeostasis. Intestinal epithelial cells (IECs) have a high turnover rate driven by the death of terminally differentiated cells with concurrent stem cell proliferation, a process critical for maintaining intestinal homeostasis and protecting against mucosal inflammation. The transcriptional programs that regulate IEC quiescence, proliferation, and differentiation have been well-characterized. However, how gene expression networks critical for IEC functions are regulated at the post-transcriptional level during homeostasis or inflammatory disease remains poorly understood. Herein, we show that a conserved family of microRNAs, miR-181, is significantly downregulated in IECs from patients with inflammatory bowel disease and mice with chemical-induced colitis. Strikingly, we showed that miR-181 expression within IECs, but not the hematopoietic system, is required for protection against the development of severe colonic inflammation in response to epithelial injury in mice. Mechanistically, we showed that miR-181 expression increases the proliferative capacity of IECs, likely through the regulation of Wnt signaling, independently of gut microbiota composition. As epithelial reconstitution is crucial for restoring intestinal homeostasis after injury, the miR-181 family represents a potential novel therapeutic target in IECs for protection against severe intestinal inflammation.

2022-07-25 | GSE208410 | GEO

Micromonospora sp. 181

Project description:Micromonospora sp. 181 Genome sequencing

| PRJNA795584 | ENA