Tribbles-1 regulates hepatic lipogenesis through post-transcriptional regulation of C/EBPα [array]

ABSTRACT: Comparison of gene expression in livers of either WT mice or mice with hepatic specific deletion of the gene Tribbles1. Animal groups were both Trib1 cKO mice homozygous for a floxed allele of Trib1. Mice aged 8-10 weeks were treated with adeno associated virus (AAV) encoding Cre recombinase (AAV_Cre) or no gene (AAV_null). The WT group is mice treated with AAV_Null, the liver-specific KO group treated with AAV_Cre. Gene expression data was then used in Ingenuity Pathway analysis to attempt to identify upstream transcription factors that might be responsible for the gene expression changes observed.

ORGANISM(S): Mus musculus

PROVIDER: GSE70846 | GEO | 2015/07/14

SECONDARY ACCESSION(S): PRJNA289681

REPOSITORIES: GEO