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Cbx8 acts non-canonically with Wdr5 to promote mammary tumorigenesis [ChIP-Seq]

ABSTRACT: Here we found that Cbx8 knockdown in MMTV-Myc and MDA-MB-231-Luc cells reduces H3K4me3 mark on Notch-network genes

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE71003 | GEO | 2016/06/21

SECONDARY ACCESSION(S): PRJNA290085

REPOSITORIES: GEO

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Cbx8 acts non-canonically with Wdr5 to promote mammary tumorigenesis [RNA-Seq]

Project description:Here we show that in MMTV-Myc cells (1) MS culture enriches for aggressive breast cancer cells compared to the bulk cells, (2) Cbx8 knockdown reduces Notch-network gene expression.

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Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis.

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Cbx8 acts non-canonically with Wdr5 to promote mammary tumorigenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

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Cbx8 acts non-canonically with Wdr5 to promote mammary tumorigenesis [ChIP-Seq]

Project description:Cbx8 acts non-canonically with Wdr5 to promote mammary tumorigenesis [ChIP-Seq]

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Expression data from human breast cancer cells MDA-MB-231-Luc knockdown for RRAS2 expression.

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